Home/CVE/Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (component: Common
CVE
CVE-2026-21997
Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (component: Common
Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (component: Common Core). Supported versions that are affected are 9.2.1-9.2.3. Easily exploitable vulnerability allows low privileged attacker with network access via HTTP to compromise Oracle Life Sciences Empirica Signal.
While the vulnerability is in Oracle Life Sciences Empirica Signal, attacks may significantly impact additional products (scope change). Successful attacks of this vulnerability can result in unauthorized creation, deletion or modification access to critical data or all Oracle Life Sciences Empirica Signal accessible data as well as unauthorized read access to a subset of Oracle Life Sciences Empirica Signal accessible data. CVSS 3.1 Base Score 8.5 (Confidentiality and Integrity impacts).
CVSS Vector: (CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:C/C:L/I:H/A:N).
HIGH · CVSS 8.5
EPSS 0.00027
EPSS exploitation odds0.03% · top 92%
Schedule remediation
- CVSS base score ≥ 7.0
No Sigma yet — build one →
YARA rules0
Look this up elsewhere - one-click external pivots
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How to read a CVE - triage first, then detect and patch
This page is every public fact about CVE-2026-21997, cross-linked. Its job is to answer one question fast - does this need my attention now? - and then hand you the two things you do about it. Here is how an analyst reads it.
Triage: should I act now? Four signals, and they are not interchangeable:
CVSSseverity - how bad it is IF exploited, 0-10. A high CVSS alone is not urgency; a flaw can be a perfect 10 and never actually be attacked.
EPSSprobability - a model’s estimate of the chance it is exploited in the next 30 days, 0-1. This is the “will it actually happen” signal.
CISA KEVconfirmed - it is being exploited in the wild right now. The strongest signal on the page; KEV beats any score.
Weaponisedavailability - public exploits / PoCs, and especially Metasploit modules rated Excellent / Great. Reliable, packaged exploit code means low-skill attackers can use it today.
How they combine: KEV, or a dependable Metasploit module, means patch now regardless of CVSS. High CVSS + low EPSS + no exploit is real but not an emergency - schedule it. Low CVSS but KEV-listed still gets patched now. The verdict above already weighed these for you; this is how it got there.
Then what - two workflows:
Detectwhen you cannot patch today, follow this CVE to the ATT&CK techniques it enables, then Build a SIEM detection (the green button) - author a rule, test it in Atomic, deploy it. That buys visibility while the patch waits.
PatchAffected products / packages tell you if you are exposed; Fixed versions by distribution and Vendor advisories give the exact version that closes it.
Reading order for the panels below: verdict + badges, then Public exploits / Metasploit (is it weaponised), then ATT&CK techniques + Sigma / IDS rules (can I detect it), then Affected products / packages + Fixed versions (am I exposed, what patches it), then Threat actors / IOCs (who uses it), then Scoring & timeline / references (the evidence).
EPSS exploitation probability
0.03%
Top 92%odds of exploitation in the next 30 days
CVSS metric silhouette
shape grows toward worst-case
SSVC triage · cisa-vulnrichment
Exploitation
none
Automatable
no
Tech impact
partial
CVSS vector breakdown
Exploitability - how they get in
Attack Vector
Network
Adjacent
Local
Physical
Attack Complexity
Low
High
Privileges Required
None
Low
High
User Interaction
None
Required
Scope
Unchanged
Changed
Impact - what breaks
Confidentiality
None
Low
High
Integrity
None
Low
High
Availability
None
Low
High
VECTOR
CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:C/C:L/I:H/A:NLifecycle
- 21 Apr 2026Published to NVD
- 01 May 2026Last modified
Every entry is a recorded date - NVD publish/modify, CISA KEV add, public exploit disclosure. No inferred events.
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ATT&CK techniques
2Techniques this CVE enables - linked via CWE → CAPEC → ATT&CK. Pills with a solid outline are named directly in ATT&CK or Nuclei templates (high confidence); the others are linked through weakness mappings.
▤ Build a SIEM detection for these techniques▤
CAPEC attack patterns
12Attack patterns this CVE enables - the bridge from weakness to ATT&CK technique.
CAPEC-CAPEC-19 · Embedding Scripts within Scripts CAPEC-CAPEC-441 · Malicious Logic Insertion CAPEC-CAPEC-478 · Modification of Windows Service Configuration CAPEC-CAPEC-479 · Malicious Root Certificate CAPEC-CAPEC-502 · Intent Spoof CAPEC-CAPEC-503 · WebView Exposure CAPEC-CAPEC-536 · Data Injected During Configuration CAPEC-CAPEC-546 · Incomplete Data Deletion in a Multi-Tenant Environment CAPEC-CAPEC-550 · Install New Service CAPEC-CAPEC-551 · Modify Existing Service CAPEC-CAPEC-552 · Install Rootkit CAPEC-CAPEC-556 · Replace File Extension Handlers
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Weakness Classification
CWE-284Improper Access Control
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Affected Products & Versions
1oracle life sciences empirica signal>= 9.2.1 and <= 9.2.3
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Related CVEs
4CVEs linked to this one by a shared weakness (CWE) or affected product - joins on data already in the engine, with the reason shown per row. Not a guess.
CVE-2001-0781
Buffer overflow in SpoonFTP 1.0.0.12 allows remote attackers to execute arbitrar...
same CWE-284
CVE-2008-2947
Cross-domain vulnerability in Microsoft Internet Explorer 5.01 SP4, 6, and 7 all...
same CWE-284
CVE-2009-2092
IBM WebSphere Application Server (WAS) 7.0 before 7.0.0.5 does not properly read...
same CWE-284
CVE-2009-2631
Multiple clientless SSL VPN products that run in web browsers, including Stoneso...
same CWE-284
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Vendor Advisories
1🔗
References & Sources
1Source URLs (vendor pages, mailing lists, write-ups). Exploit/PoC links are in their own section above to avoid duplication.
https://www.oracle.com/security-alerts/cpuapr2026.htmlVendor Advisory